It was in the early 1990s that Talisa and Benjamin first met at a movie audition. But they didn't become a couple until a decade later when they co-starred in the film Piñero together, and their relationship became very serious very quickly.

"She was a very famous model and actor; she was a Bond girl. Within six months after consummating our affair, I got down on a knee and proposed," Benjamin recalled to Esquire in 2022.

The couple married in San Francisco in April 2002, less than a year after Benjamin's high-profile split from Hollywood actress Julia Roberts. Soon after, Talisa retired from acting to focus on family life, and her last film appearance was in the 2009 movie La Mission, directed by her brother-in-law Peter Bratt.

Although Talisa and Benjamin share few details about their private life, they are parents to two children daughter Sophia, born in 2002, and son Mateo, born in 2005.

"Falling in love with Talisa cemented what I’ve instinctually always known: Above being an artist, even above defining myself as an actor, I see myself as a husband and a father first," Benjamin said. "I don’t know if that’s been a hindrance or a help in terms of the professional path I’ve been on, but at this point it’s hard to really care too much about it.”

In a 2022 interview, Benjamin revealed that their daughter had experienced a brain injury at birth, which had impacted their lives together and many of the decisions they had made. "Almost everything we do, every decision we make personally and professionally, is informed by our daughter, Sophia, and her needs. She incurred a brain injury at birth, so she faces a host of challenges," he said.

Singing his wife's praises, the actor added of Talisa: "Raising children, especially one who is as challenged as our daughter, is physically and emotionally exhausting. My wife carries the brunt of it because when I go off to work, she is left behind. She’s my hero."

In 2022, Benjamin also disclosed that Talisa had been diagnosed with breast cancer during the COVID-19 pandemic, and had encouraged him to share her story in an effort to encourage women to "get your screenings yearly, that you have to self-advocate for yourself and take care of yourself."